Describe the murmur of Tetralogy of Fallot.

The murmur associated with Tetralogy of Fallot is characterized as a holosystolic (or pansystolic) murmur that is best heard at the left sternal border. This configuration arises from the ventricular septal defect (VSD) that is part of the tetralogy and the right ventricular outflow tract (RVOT) obstruction.

In this condition, blood flow is directed from the right ventricle through the VSD into the left ventricle during systole, creating turbulence. The resulting murmur is continuous throughout systole and is often described as having a quality similar to a "machine-like" sound due to the persistence of this flow across the entire systolic phase. Its best auscultatory location is at the left sternal border, correlating with the anatomical locations of both the VSD and the pulmonary outflow tract obstruction.

Understanding these murmur characteristics is crucial for recognizing this congenital heart defect. The other options do not accurately describe the murmur found in Tetralogy of Fallot, as they refer to different types of murmurs typically associated with other cardiac conditions, such as those arising from aortic or mitral valve problems.