Reye syndrome is associated with viral infection and which medication?

Reye syndrome is a rare but serious condition that primarily affects children and is characterized by acute encephalopathy and fatty liver degeneration. It has been strongly associated with the use of aspirin in children who are recovering from viral infections, most notably influenza and varicella (chickenpox). The precise mechanism by which aspirin contributes to the development of Reye syndrome is not fully understood; however, it is believed that aspirin may promote mitochondrial dysfunction or impaired fatty acid metabolism in the liver when combined with certain viral infections.

The recommendation is thus to avoid aspirin in children, particularly during viral illnesses, to reduce the risk of Reye syndrome. Other common medications such as ibuprofen, acetaminophen, and naproxen are not linked to Reye syndrome and are often used as alternative analgesics and antipyretics in pediatric patients when necessary. This understanding is crucial for safe medication practices in children, especially those recovering from viral infections.