What are common causes of Torsades de Pointes?

Torsades de Pointes (TdP) is a specific form of polymorphic ventricular tachycardia that is often associated with prolonged QT interval, which can lead to serious cardiac arrhythmias. The correct choice identifies low magnesium or potassium levels as common causes of TdP.

Electrolyte imbalances, particularly low levels of magnesium and potassium (hypomagnesemia and hypokalemia), can significantly affect cardiac repolarization and contribute to the development of TdP. These electrolytes play crucial roles in stabilizing the myocardial cell membrane potential. When levels are low, the likelihood of developing a prolonged QT interval increases, which is a predisposing factor for TdP.

In contrast, while high calcium levels can also influence cardiac function, they are less commonly implicated in TdP compared to the effects of low magnesium or potassium. Severe hypertension and coronary artery disease are associated with various cardiac complications but are not direct causes of TdP. The connection of TdP with electrolyte disturbances emphasizes the need for careful monitoring of these electrolytes, particularly in patients who are at risk for arrhythmias.