What are the causes of folate deficiency?

Folate deficiency can be primarily attributed to dietary inadequacies and the influence of certain medications, particularly antiepileptic drugs such as phenytoin. Folate, a B vitamin, is essential for DNA synthesis and repair, as well as for cell division. A diet lacking in green leafy vegetables, fruits, and fortified grains can lead to a deficiency.

In addition, medications like phenytoin can interfere with the metabolism and utilization of folate, thereby contributing to its deficiency. Other drugs that may impact folate levels include methotrexate and sulfasalazine, commonly used in the treatment of autoimmune conditions and cancer.

Therefore, considering the role of dietary intake and specific medications in the development of folate deficiency, this answer accurately encompasses the significant causes of folate deficiency.