What are the most common symptoms of primary sclerosing cholangitis?

Primary sclerosing cholangitis (PSC) is a chronic liver disease characterized by progressive inflammation and scarring of the bile ducts. The symptoms most commonly associated with this condition include pruritus, or intense itching, and jaundice, which is the yellowing of the skin and eyes due to the accumulation of bilirubin in the bloodstream.

Pruritus occurs because of the buildup of bile acids in the bloodstream, leading to irritating sensations on the skin. Jaundice develops as the liver's ability to excrete bile is compromised, causing bilirubin levels to rise. These symptoms are indicative of the underlying cholestasis and damage to the bile ducts that define PSC.

While other symptoms may be present in the course of the disease or associated conditions, pruritus and jaundice are the hallmark signs that are most frequently noted in patients with primary sclerosing cholangitis. Thus, the emphasis on these symptoms in the context of PSC highlights their critical role in identifying and managing the disease effectively.