What are the three most common causes of unconjugated hyperbilirubinemia?

The three most common causes of unconjugated hyperbilirubinemia are Physiologic jaundice, prematurity, and breast feeding.

Physiologic jaundice typically occurs in newborns shortly after birth due to the immature hepatic uptake and conjugation of bilirubin. This condition usually resolves without intervention in healthy term infants.

Prematurity also plays a significant role, as premature infants have an even more immature liver function, making them more susceptible to unconjugated hyperbilirubinemia. This condition can lead to higher bilirubin levels as their livers are less efficient at processing bilirubin.

Breastfeeding can contribute to unconjugated hyperbilirubinemia, particularly when babies are not feeding well or if the mother’s milk is delayed. This can lead to increased levels of bilirubin due to inadequate fluid intake and resultant dehydration, causing increased breakdown of red blood cells.

The other options present causes that, while important in different clinical contexts, do not represent the three most common causes of unconjugated hyperbilirubinemia specifically in newborns. Understanding these distinctions is crucial for accurate diagnosis and management in pediatric patients.