What are the typical clinical features of von Willebrand's disease?

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Von Willebrand's disease is a common inherited bleeding disorder characterized primarily by the inability of platelets to properly function in blood coagulation due to a deficiency or dysfunction of von Willebrand factor (vWF). The typical clinical features of this condition include bleeding tendencies such as frequent nosebleeds, easy bruising, and prolonged bleeding from cuts or during menstruation. Patients may also experience excessive bleeding after surgical procedures or dental work.

The presence of easy bruising and bleeding is a direct consequence of the impaired platelet aggregation caused by the lack of vWF. This makes option B the correct answer, as it encapsulates the hallmark symptoms associated with von Willebrand's disease. In contrast, the other options do not align with the defining characteristics of this bleeding disorder: high blood pressure and fatigue are not specific to von Willebrand's disease, while joint pain and swelling commonly relate more to hemophilia or arthritis, and an elevated white cell count is typically indicative of infections or other hematological conditions, rather than a bleeding disorder.

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