What is a common laboratory finding in Multiple Myeloma?

In Multiple Myeloma, one of the hallmark laboratory findings is the presence of Bence Jones proteins in the urine, which are free light chains of immunoglobulins. The disease is characterized by abnormal plasma cells that overproduce these light chains, leading to their excretion in the urine. Additionally, rouleaux formation of red blood cells is commonly observed in Multiple Myeloma due to the increased serum proteins, which causes the red blood cells to stack together like coins. This finding is a direct consequence of the hyperviscosity and altered plasma characteristics related to the disease.

The other options reflect conditions that may arise in various hematologic or renal disorders but are not specific indicators of Multiple Myeloma. Elevated white blood cell counts are more commonly associated with infections or other conditions, while high levels of creatinine suggest renal impairment, which can occur but is not a primary finding. Lastly, decreased platelet counts can occur in various conditions due to multiple factors, including bone marrow involvement but do not specifically indicate Multiple Myeloma. Thus, the presence of rouleaux RBCs and Bence Jones protein in urine provides a clear and specific laboratory signature of Multiple Myeloma.