What is a common outcome associated with Brugada syndrome?

Brugada syndrome is a genetic disorder characterized by specific abnormalities in the heart's electrical activity, which can lead to life-threatening arrhythmias. One of the most concerning and well-documented outcomes of this syndrome is the risk of sudden cardiac death, often occurring at night or during sleep, hence the term "sudden nocturnal death."

Patients with Brugada syndrome have a heightened risk for ventricular fibrillation and, consequently, sudden cardiac arrest. This risk is particularly acute among younger individuals, often males, and can occur without prior warning or symptoms. Therefore, the association of Brugada syndrome with sudden nocturnal death highlights the critical nature of monitoring and potentially managing patients diagnosed with this condition to prevent fatal outcomes.

In contrast to the other options listed, such as pacemaker dependency, coronary artery disease, or heart failure, these conditions are not commonly linked to Brugada syndrome. While individuals with the syndrome may have arrhythmias that require monitoring or at times the use of an implantable defibrillator, reliance on a pacemaker is not typical. Additionally, coronary artery disease and heart failure primarily relate to other cardiovascular issues rather than Brugada syndrome specifically.