What is one of the main side effects of Rifampin?

One of the main side effects of Rifampin is the orange discoloration of body fluids. This occurs because Rifampin is a potent antibiotic that affects not only the bacteria but also the body's metabolic processes, leading to the alteration of normal pigmentation in secretions. As the drug is metabolized and excreted, it can impart a reddish-orange hue to urine, sweat, saliva, and tears. This side effect is notable and important for patients to be aware of, as it can cause alarm or concern if they are not forewarned.

This change in body fluid color does not indicate any harm or toxicity; rather, it’s a benign and expected effect of the medication's action on the body. It's essential for healthcare providers to educate patients about this effect to help them differentiate between a normal reaction to the medication and other potential signs of adverse reactions.