What is the first line treatment for uncomplicated cystitis?

The first-line treatment for uncomplicated cystitis is Nitrofurantoin. This antibiotic is preferred due to its effectiveness against the most common causative organisms of urinary tract infections (UTIs), particularly Escherichia coli. Nitrofurantoin works specifically by targeting the bacteria in the urinary tract and is well-tolerated by most patients.

In addition to its effectiveness, Nitrofurantoin has a relatively low risk of developing antibiotic resistance compared to some other antibiotic options. It is also less likely to disrupt the normal flora of the gastrointestinal tract, making it a favorable choice.

Other antibiotics mention potential options for treating UTIs, but they may not be the best initial choice for uncomplicated cystitis. For example, while Ciprofloxacin is a broad-spectrum fluoroquinolone that is effective against a wide range of pathogens, it is typically reserved for more complicated cases or when first-line agents are contraindicated due to resistance patterns or patient allergy history. Cephalexin and Amoxicillin might be effective for treating UTIs but have more limitations in terms of resistance and the specific pathogens they eradiate.

In summary, Nitrofurantoin is the preferred first-line therapy for uncomplicated cystitis as it is effective, has a favorable resistance profile