What is the most common congenital coagulopathy?

von Willebrand disease is recognized as the most common congenital coagulopathy. This condition is characterized by a deficiency or dysfunction in von Willebrand factor, a critical plasma protein involved in blood clotting. This factor plays a significant role in the aggregation of platelets and stabilizing factor VIII, which is essential for effective clot formation.

The prevalence of von Willebrand disease surpasses other congenital coagulation disorders, as it affects a larger segment of the population. It can lead to varying degrees of bleeding, often presenting with symptoms such as easy bruising, frequent nosebleeds, and excessive bleeding after injury or surgery.

In contrast, while Hemophilia A is a well-known coagulopathy, it mainly affects males and has a lower incidence compared to von Willebrand disease. Factor V Leiden and hyperprothrombinemia are associated more with thrombophilia, leading to increased clotting rather than bleeding issues. Thus, understanding the nature and impact of von Willebrand disease helps to clarify its position as the predominant congenital coagulopathy.