What is the primary treatment approach for Polyarteritis nodosa?

The primary treatment approach for Polyarteritis nodosa (PAN) is high dose steroids. This condition is a type of systemic vasculitis that primarily affects medium-sized muscular arteries, leading to symptoms related to organ ischemia and inflammation. High dose corticosteroids are used to reduce inflammation and suppress the immune response, which can help alleviate symptoms and prevent further vascular damage.

Corticosteroids have been established as effective for managing PAN in both acute and chronic cases. The use of steroids helps to control the systemic inflammatory process and can lead to significant improvements in patient outcomes. In some cases, immunosuppressive agents may also be utilized as part of a treatment strategy, especially in cases that do not respond adequately to corticosteroids or when there is a need for long-term management; however, high dose steroids remain the cornerstone of initial therapy.

The other treatment options listed do not address the underlying inflammatory mechanism of Polyarteritis nodosa. Biologics are typically used in other autoimmune or inflammatory diseases, and while they can be effective in treating some types of vasculitis, they are not first-line for PAN. Physical therapy may be useful for rehabilitation in certain cases but does not treat the underlying disease. Antibiotics would not be effective since Polyarteritis