What other gastrointestinal disease is associated with Ulcerative colitis?

Ulcerative colitis, a form of inflammatory bowel disease (IBD), has several associated extraintestinal manifestations and comorbid conditions. Among these, primary sclerosing cholangitis (PSC) is particularly noteworthy. PSC is a disease that affects the bile ducts, leading to inflammation and scarring, which can ultimately result in liver damage. Studies have shown a strong association between ulcerative colitis and PSC, especially in patients with more severe forms of colitis. The two conditions share similar immunological pathways and genetic factors, which helps explain this association.

The link between ulcerative colitis and PSC is particularly significant as it may necessitate ongoing monitoring of liver function and the potential for complications arising from cholestasis and bile duct cancer. Understanding this connection is crucial for holistic patient management and care.