What physical change might be seen in patients with Cushing's disease?

In patients with Cushing's disease, the correct choice highlights a common physical manifestation related to the disease process. Cushing's disease results from excessive cortisol levels in the body, which can lead to several dermatological changes, one of the most notable being thin skin and easy bruising. The elevated cortisol levels affect collagen and other components of the skin's structural integrity, making the skin more fragile. This fragility contributes not only to a thinner appearance but also to a susceptibility to bruising from minor trauma, as the skin cannot effectively support its usual protective functions.

In the context of other options, while thickened skin and calluses, rapid weight loss, and skin discoloration may occur in different medical conditions or contexts, they are not hallmark features of Cushing's disease. The disease typically leads to weight gain, particularly in the abdominal and facial regions, rather than weight loss. Skin discoloration can happen, but it is not as characteristic or prevalent as the thinning of the skin and easy bruising in patients suffering from this condition.