What treatment in PCOS is known to improve hirsutism, lipid and glucose parameters, and fertility?

The treatment known to improve hirsutism, lipid and glucose parameters, and fertility in patients with polycystic ovary syndrome (PCOS) is weight loss.

In PCOS, many patients experience insulin resistance, which can lead to weight gain and exacerbate symptoms such as hirsutism, dyslipidemia, and difficulties with fertility. Weight loss, even a modest reduction of about 5-10% of body weight, can significantly enhance insulin sensitivity, which in turn may help regulate menstrual cycles and improve ovulation. This weight loss can also lead to reductions in circulating androgens, thus reducing hirsutism. Additionally, improving lifestyle through weight management has been shown to positively impact lipid profiles and glucose metabolism, which are often affected in individuals with PCOS.

In contrast, while other treatments like hormonal contraception, metformin, and clomiphene citrate may have benefits for PCOS management, they do not universally address all three aspects—hirsutism, lipid and glucose parameters, and fertility—like weight loss does. Instead, these treatments often focus on specific symptoms or issues associated with the syndrome.