Which autoimmune disorder is known for inflammation, positive ANA, and multiple organ involvement?

Systemic Lupus Erythematosus (SLE) is a significant autoimmune disorder characterized by widespread inflammation that can affect multiple organs, including the skin, joints, kidneys, and heart. One of the hallmark features of SLE is the presence of antinuclear antibodies (ANA), which are commonly found in individuals with the condition. This positive ANA test can aid in the diagnosis, although it is not exclusive to SLE, as it can also be seen in other autoimmune disorders.

The multi-organ involvement in SLE is particularly notable, as patients may present with symptoms affecting various systems, leading to a diverse array of manifestations, including systemic symptoms like fatigue and fever, as well as specific organ-related symptoms, such as a characteristic butterfly rash on the face or pleuritic chest pain due to lung involvement.

In contrast, other listed conditions, while also autoimmune in nature, do not share the same level of multi-systemic involvement or are connected with different specific features. For instance, rheumatoid arthritis primarily impacts the joints and may display positive ANA but lacks the extensive systemic inflammation characteristic of SLE. Psoriatic arthritis also predominantly affects the skin and joints, while Hashimoto's thyroiditis primarily involves the thyroid gland without the systemic organ involvement typical