Which complication is a potential result of elevated uric acid levels caused by HCTZ?

Elevated uric acid levels, often a consequence of thiazide diuretics like hydrochlorothiazide (HCTZ), can lead to gout. Gout is a type of inflammatory arthritis characterized by sudden and severe episodes of pain, redness, and swelling in joints, particularly in the big toe. When uric acid levels in the blood exceed normal limits, it can crystallize in the joints, causing intense pain and inflammation associated with gout attacks.

HCTZ can increase uric acid levels by reducing the kidney's ability to excrete uric acid. Therefore, patients on HCTZ may be at a higher risk for developing gout due to this mechanism. Understanding the relationship between thiazides, elevated uric acid, and the development of gout is essential for managing patients who require diuretic therapy while minimizing complications. In this context, addressing uric acid levels is critical in the overall management of patient care involving thiazide use.