Which demographic is most likely to be affected by Pemphigus vulgaris?

Pemphigus vulgaris is an autoimmune blistering disorder primarily affecting the skin and mucous membranes. The condition is especially prevalent among middle-aged individuals, particularly those of Jewish or Mediterranean descent. This demographic is most commonly affected due to genetic predispositions that may contribute to the autoimmune processes underlying the disease.

Autoimmune conditions like pemphigus vulgaris often show variations in incidence based on ethnic backgrounds, with certain populations experiencing higher rates due to specific genetic markers and environmental factors. Therefore, middle-aged Jewish and Mediterranean adults stand out as the primary affected group, making this choice the most accurate.

The other demographics, while they may experience other health conditions, do not have the same strong association with pemphigus vulgaris as seen in the specified group. For instance, the condition is not particularly prevalent in African American adults, Asian adults, or children under 12, which reflects the unique demographic risk factors linked to pemphigus vulgaris.