Which is NOT one of the classic signs of infective endocarditis?

Pitting edema is not considered one of the classic signs of infective endocarditis. The classic signs are typically recognized as Roth spots, splinter hemorrhages, and Osler's nodes.

Roth spots are retinal findings associated with endocarditis that appear as white, fluffy exudates surrounded by a halo of retinal hemorrhage. These spots result from embolization of infectious material or immune complexes affecting the retinal vessels.

Splinter hemorrhages, which are small, linear streaks of blood found under the fingernails or toenails, occur due to small emboli that lodge in the small vessels of the nail beds. They are a direct result of the systemic spread of infectious agents or embolic phenomena related to the disease process.

Osler's nodes are painful, raised lesions found on the palms and soles, developed as a result of immune complex deposition and inflammation. They indicate a more severe systemic effect of the infection.

In contrast, pitting edema refers to a condition where pressure applied to a swollen area leaves an indentation. It is commonly associated with various general medical conditions, such as heart failure or venous insufficiency. Since pitting edema does not specifically indicate the presence of infective endocarditis or result from the same