Which medication is known to prolong life in CHF patients?

ACE inhibitors are known to prolong life in patients with congestive heart failure (CHF) due to their beneficial effects on cardiac function and structure. They work by inhibiting the angiotensin-converting enzyme, which leads to vasodilation, reduced blood pressure, and decreased workload on the heart. By blocking the conversion of angiotensin I to angiotensin II, ACE inhibitors help to decrease the secretion of aldosterone and reduce fluid retention, contributing to improved symptoms of heart failure.

Clinical studies have shown that ACE inhibitors not only relieve symptoms but also improve survival rates in patients with CHF, especially those with reduced ejection fractions. This has made them a cornerstone in the management of this condition.

In contrast, while calcium channel blockers can provide symptomatic relief and help reduce heart rate, they are not typically recommended for systolic heart failure due to concerns about worsening outcomes. Diuretics are effective for managing fluid overload but do not affect mortality. Nitrates can alleviate symptoms of heart failure by providing vasodilation, yet they do not have a significant impact on survival rates in the long term. Thus, ACE inhibitors stand out as the only choice among the options listed that has a proven effect on prolonging life in CHF patients.