Which of the following are typical complaints in Multiple Myeloma?

Multiple Myeloma is characterized by several clinical features linked to the proliferation of abnormal plasma cells in the bone marrow. The typical complaints include bone pain, which results from osteolytic lesions caused by the malignant cells, leading to damage to the bone structure. Patients often also experience anemia due to the decreased production of normal red blood cells, as the cancerous plasma cells crowd out healthy hematopoietic cells in the bone marrow. Furthermore, an increased susceptibility to infections is common in these patients, stemming from impaired immune function associated with the disease and the effects of treatments.

While bone pain is a significant and prevalent symptom, the mention of hemorrhage in the first option is less typical in the context of Multiple Myeloma. It is more often related to disorders affecting blood clotting or platelet function. The symptoms in the third option, such as fatigue and weight loss, are common in a variety of cancers, but confusion is not a hallmark symptom of Multiple Myeloma specifically. The last option highlights respiratory issues and kidney problems, which, although kidney impairment can be associated due to hypercalcemia or renal failure secondary to myeloma, joint pain and respiratory issues are not characteristic complaints directly linked to Multiple Myeloma itself.

Thus, the