Which of the following is NOT a typical symptom of Cushing's disease?

Cushing's disease is characterized by excess cortisol production, which leads to a range of symptoms due to the metabolic effects of elevated cortisol levels. Common features include truncal obesity, where fat accumulates primarily in the trunk, and the presence of a buffalo hump, which is fat deposit at the back of the neck. Virilism, or the development of male secondary sexual characteristics due to high levels of androgens, can also occur in some cases due to adrenal hypersecretion in Cushing's disease.

Weight loss, on the other hand, is generally not associated with Cushing's disease. In fact, patients typically experience weight gain and increased fat deposits as a direct consequence of the hormonal imbalances present in this condition. Therefore, weight loss is the option that does not align with the common symptoms of Cushing's disease, making it the correct choice in identifying what is NOT typical of the condition.