Which statement is related to the management of dysmenorrhea?

The recommendation for NSAIDs (non-steroidal anti-inflammatory drugs) within 48 hours of symptoms is grounded in the pathophysiology of dysmenorrhea, which involves the release of prostaglandins that cause uterine contractions and pain. Starting NSAIDs early, ideally when symptoms first appear, can help to effectively reduce pain and inflammation. This proactive approach is supported by clinical guidelines, which suggest that NSAIDs are a first-line treatment for managing primary dysmenorrhea.

While physical therapy and lifestyle modifications such as dietary changes can play roles in the holistic management of dysmenorrhea, they are generally not considered immediate or primary interventions for acute pain relief. Similarly, while antidepressants may be utilized in some cases—particularly when pain is chronic or related to other mood disorders—they are not the standard first-line treatment for dysmenorrhea itself. Thus, the recommendation regarding NSAIDs is a key aspect of effective management strategies for dysmenorrhea.