Which two diseases are commonly associated with HLA B27?

The association of HLA B27 with certain diseases is well established in medical literature. Ankylosing spondylitis and reactive arthritis are among the conditions that consistently show a significant correlation with the presence of HLA B27.

Ankylosing spondylitis is a type of inflammatory arthritis that primarily affects the spine and pelvis, leading to pain and stiffness. The role of HLA B27 in this condition is particularly notable, as a large percentage of individuals with ankylosing spondylitis test positive for this antigen. The presence of HLA B27 seems to be associated with an increased risk of developing this disease, which connects it to the underlying inflammatory processes.

Reactive arthritis, another disease associated with HLA B27, is a condition that occurs in response to an infection in another part of the body, commonly in the urogenital or gastrointestinal tracts. Like ankylosing spondylitis, there is a strong link between HLA B27 positivity and the likelihood of developing reactive arthritis.

This strong association between HLA B27 and these two diseases highlights the antigen’s role in predisposing individuals to certain autoimmune and inflammatory responses. Other options, while involving important diseases, do not share the same strong link with H